The immune system that mediates pathogen clearance and tissue healing, and the DNA repair system that protects our genome are the primary defence system against external and internal threats. Dysregulations in these systems lay at the core of many health afflictions, including infections, autoimmune/inflammatory diseases, neurodegeneration, cancer and many age-associated health afflictions. Current research efforts are focused on the crosstalk between these defence systems, the regulatory components involved and how to target these components in disease management. Diseases of current interest include infections, inflammatory diseases and cancer. We apply multidisciplinary approaches combining cutting-edge microscopy, in vivo (in mice) imaging techniques for monitoring infections, tumors and inflammatory processes, as well as molecular/cell biology and biochemical approaches for studying protein-protein interactions and post-translational modifications. Our goal is understand fundamental biological processes with the view that some of our discoveries will benefit human health.