The immune system that mediates pathogen clearance and tissue healing, and the DNA repair system that protects our genome are essential for life, and dysregulations in these defense systems are at the core of most diseases, including infections, autoimmune/inflammatory diseases, neurodegeneration, cancer and many age-associated health decline. The overall goal of the project is to understand how the innate immune and DNA repair systems cross-communicate with each other, identify regulatory components involved and devise ways to target these components in disease management. Diseases of current interest include infections, inflammatory diseases and cancer. We apply multidisciplinary approaches combining cutting-edge microscopy, in vivo (in mice) imaging techniques for monitoring infections, tumors and inflammatory processes, as well as molecular/cell biology and biochemical approaches for studying protein-protein interactions and post-translational modifications. Candidates with experience in immunology, molecular or cell biology and biochemistry are specifically encouraged to apply.