Universitätsklinikum Heidelberg
Heidelberg
wanted for the next possible date at the laboratory of Prof. Dr. Oliver T. Fackler, Center for Infectious Diseases, Integrative Virology, CIID, University Hospital Heidelberg, Germany.
The laboratory is located in the Center for Integrative Infectious Disease (CIID) with its state-of-the art imaging facility at the heart of the Heidelberg life science campus. We offer an international and highly interactive environment to address projects at the interface of immunology, biochemistry, cell biology, and virology.
The projects start in fall 2023 and address two aspects of HIV-1 pathogenesis:
Targeting the HIV-1 pathogenesis factor Nef
The Nef protein of HIV-1 is key for pathogenesis and disease progression by serving as versatile protein interaction adaptor that rewires many host cell properties and pathways to the benefit of the virus. Owing to its multiple functions and relevant protein-interaction motifs, Nef is not yet targeted therapeutically. We recently identified a protein interaction surface that mediates all cardinal Nef functions (Ananth et al., 2019, J. Virol.; Kaw et al., 2020, Embo J). The goal of the project is to develop a microscopy-based screening platform to identify lead compounds of a broadly acting Nef inhibitor and to dissect the mechanism of action of this protein interaction surface. This will involve the development of an advanced microscopy acquisition and analysis pipeline and applying immunology, biochemistry and cell biology approaches. For this project, we are looking for candidates with strong background in microscopy and cell biology.
Dissecting innate immune restrictions to HIV-1 in resting CD4 T cells
Homepage https://ciid-heidelberg.de/research-groups/fackler/
Please send your applications (including letter of motivation and full CV with publication record, high school and university diplomas, record of transcripts) to:
Computational Biologist (E13 or E14) München Vollzeit Technische Universität München PhD student position (m/f/d): Immune checkpoints of gut to brain communication in inflammatory and neurodegenerative diseases (GB.Com) Erlangen Vollzeit Universitätsklinikum Erlangen PhD Student in Neuroimmunology Hamburg Vollzeit UKE - Universitätsklinikum Hamburg-Eppendorf
2 PhD Students (m/f/d) Freiburg Vollzeit Universitätsklinikum Freiburg