- Use cell lines and mouse models to investigate the intersection between immunity, metabolism and inflammation
- Use immunology, biochemistry, and computational techniques to investigate metabolism at the molecular level in immune cells
- Perform multi-omics analyses (metabolic, proteomic and transcriptomic studies) and integrate these datasets to generate new hypotheses
- To accurately record and judiciously analyse, present, and report experimental data
- Drive your own research project under the supervision of the PI
- Interact and train junior members and technicians in the lab
The Postdoc project of the successful candidate will be part of a unique and novel multidisciplinary consortium on “Immunometabolism in Health and Disease (iHEAD)”. This consortium investigates the intersection between immunity, metabolism and inflammation. The candidate will work specifically on the role of nucleotide metabolism in the activation of macrophages.
- A PhD in biology, biochemistry, immunology or equivalent is essential
- Established experience in cellular metabolism or immunology is essential
- Knowledge of research procedures and statistical methods is essential
- The ability to work effectively in a team is a prerequisite
- Experience in mouse models is desirable. The candidate needs to hold an animal license and have experience in writing animal protocols
- A research background in immunometabolism is a plus
- Proficiency in written and spoken English is mandatory
- Evidence of great communication skills, curiosity-driven science and excellent problem-solving skills is essential
- A varied job in a highly interesting and challenging research topic
- A fair working environment with appreciative cooperation
- Possibility to develop side projects according to personal interests
- Internal and external training opportunities
- Flexible working time models to support family life
- Occupational health management offers
CECAD is an inclusive, equal opportunity employer that offers attractive conditions and benefits commensurate with an international research organization with a very collegial and family-friendly work environment.
The Frezza laboratory (https://frezza.cecad-labs.uni-koeln.de) seeks to understand the contribution of dysregulated metabolism to ageing-associated disorders, focusing on cancer. A part of the lab is investigating how the loss of the mitochondrial enzyme and tumour suppressor Fumarate Hydratase causes renal cancer. Our work has multiple implications: (1) it will provide a mechanistic understanding of the role of metabolism and small molecule metabolites in human diseases; (2) it will generate experimental and computation tools to identify metabolic vulnerabilities that we can use as pharmacological targets for cancer therapy; (3) it will apply metabolomics and multi-omics analyses, to mouse and human models to identify metabolic markers of disease initiation for clinical application in early detection and for patient stratification.