Stichworte
Zusammenfassung
Das Universitätsklinikum Köln AöR sucht einen motivierten PhD-Studenten (f/m/x) zur Erforschung der Mechanismen von Genominstabilität und DNA-Reparatur. Im Jachimowicz-Labor werden alters- und krebsbedingte Signalwege untersucht, die durch defekte DNA-Reparatur entstehen. Der Fokus liegt auf der Rolle von Ubiquilin-Proteinen bei der Aufrechterhaltung von DNA-Reparaturwegen. Die Stelle ist zunächst auf 3 Jahre befristet und bietet ein hervorragendes wissenschaftliches Umfeld.
Benefits und Qualifikationen
- Intensive Betreuung
- Interaktion mit globalen Führungskräften
- Standort am Max-Planck-Institut für Biologie des Alterns
Stellenausschreibung
The Jachimowicz lab "Mechanisms of DNA Repair” is seeking a talented PhD student (f/m/x) to investigate how defective DNA repair processes rewire ageing- and cancer pathways. This part-time position (25 hours / week), initially limited to 3 years, offers an exciting opportunity to contribute to cutting-edge research.
Your Mission
Your tasks include, but are not limited to, in vitro studies of the ubiquilin family members to find out how ubiquilins are recruited to their target proteins and subsequently facilitate their degradation. You will investigate this by using our available panel of genetically modified mammalian cell lines and state-of-the-art molecular biology methods. Work with mouse models is not mandatory but would be possible.
Your Profile
We are looking for candidates with a Master‘s degree and a solid background in molecular biology, cell biology, genetics, biochemistry, or bioinformatics. Experience in the field of genome instability or DNA biology is a plus. A keen interest in DNA repair mechanisms and cancer is essential. The working language is English; knowledge of German is not required.
Our Offer
We offer a great work environment, intensive mentoring and several interactions with global leaders. Our dynamic group is located at the Max-Planck Institute for Biology of Ageing (MPI-Age), which is equipped with state-of-the-art technology and excellent core facilities. The institute provides outstanding research opportunities for its scientists. At the moment, we host employees from more than 35 different nations worldwide.
Your Future
Working at the University Hospital Cologne and the Medical Faculty means helping to shape the future - the future of medicine, of patients and, of course, your own future. You benefit from 60 clinics and institutes as well as numerous other departments and facilities and more than 12,000 jobs.
You will analyze molecular mechanisms underlying role of ubiquilin proteins in DNA repair lymphomas in a small, interdisziplinary team of dedicated scientists and clinicians. You will be able to learn a wide range of methods, from basic biochemistry techniques and cell culture to working with mouse models. We link basic research and the application of new findings with translational research.
Applications from female candidates are expressly welcome and will be given priority in the event of equal suitability, competence and professional performance.
People with disabilities are welcome to apply and will be treated preferentially in the event of equal suitability and qualification.
Contact:
Dr. Melanie Thelen
+49 221 37970-586
https://www.uk-koeln.de
Application deadline: 26.11.2023